CRC - Colorectal Back

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iCoMut Beta for


Highly significantly mutated genes
APC
179 patients (76%)
TP53
122 patients (52%)
KRAS
102 patients (43%)
PIK3CA
46 patients (19%)
FBXW7
39 patients (16%)
SMAD4
28 patients (12%)
TCF7L2
23 patients (9%)
NRAS
22 patients (9%)
BRAF
22 patients (9%)
SMAD2
16 patients (6%)
PCBP1
6 patients (2%)
Significantly mutated genes
ARID1A
20 patients (8%)
ACVR1B
14 patients (6%)
ERBB3
14 patients (6%)
AXIN2
14 patients (6%)
CDC27
13 patients (5%)
CASP8
10 patients (4%)
ELF3
8 patients (3%)
NTN4
7 patients (3%)
B2M
5 patients (2%)
GOT1
5 patients (2%)
TRIM23
4 patients (1%)
SIRT4
4 patients (1%)
Genes near significance
FAM123B
26 patients (11%)
KIAA1804
15 patients (6%)
ARID2
15 patients (6%)
MSH6
12 patients (5%)
MIER3
11 patients (4%)
MAP2K4
11 patients (4%)
CTNNB1
11 patients (4%)
ERBB2
10 patients (4%)
BCLAF1
9 patients (3%)
BCOR
9 patients (3%)
NR4A2
8 patients (3%)
RBM10
8 patients (3%)
IDH2
8 patients (3%)
PTEN
8 patients (3%)
CNBD1
7 patients (3%)
TRAF3
6 patients (2%)
CD70
5 patients (2%)
Click on a gene to see details.

Notes


• Gene name color indicates: known cancer genes | highly compelling novel candidate cancer genes | other candidates

Data details


Mutation list for CRC
Q-Q plots for CRC