BCL6 co-repressor

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NCBI Description of BCOR

The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.

Community Annotation of BCOR Add / Edit BCOR: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


BCOR is highly significantly mutated in
combined cohort
111 patients (2%)
BCOR is significantly mutated in
36 patients (14%)
BCOR is near significance in
9 patients (3%)
Glioblastoma multiforme
7 patients (2%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for BCOR