B2M Back


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NCBI Description of B2M

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

Community Annotation of B2M Add / Edit B2M: Annotations

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Sort mutations by: Tumor type  Mutation type  Position  
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


B2M is highly significantly mutated in
combined cohort
36 patients (0%)
B2M is significantly mutated in
5 patients (2%)
Head and neck
7 patients (1%)
B2M is near significance in
Diffuse large B-cell lymphoma
6 patients (10%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for B2M