IDH2 Back

isocitrate dehydrogenase 2 (NADP+), mitochondrial

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NCBI Description of IDH2

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Community Annotation of IDH2 Add / Edit IDH2: Annotations

No community annotations yet for IDH2.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


IDH2 is highly significantly mutated in
Acute myeloid leukemia
20 patients (10%)
combined cohort
39 patients (0%)
IDH2 is significantly mutated in
IDH2 is near significance in
8 patients (3%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for IDH2