TCF7L2 Back

transcription factor 7-like 2 (T-cell specific, HMG-box)

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NCBI Description of TCF7L2

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

Community Annotation of TCF7L2 Add / Edit TCF7L2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TCF7L2 is highly significantly mutated in
23 patients (9%)
TCF7L2 is significantly mutated in
TCF7L2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TCF7L2