TRAF3 Back

TNF receptor-associated factor 3

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NCBI Description of TRAF3

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.

Community Annotation of TRAF3 Add / Edit TRAF3: Annotations

No community annotations yet for TRAF3.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TRAF3 is highly significantly mutated in
TRAF3 is significantly mutated in
Multiple myeloma
7 patients (3%)
TRAF3 is near significance in
6 patients (2%)
combined cohort
37 patients (0%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TRAF3