PIK3CA Back

phosphoinositide-3-kinase, catalytic, alpha polypeptide

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NCBI Description of PIK3CA
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PIK3CA is highly significantly mutated in
Endometrial
UCEC
133 patients (53%)
Breast
BRCA
291 patients (32%)
Colorectal
CRC
46 patients (19%)
Head and neck
HNSC
70 patients (18%)
Bladder
BLCA
18 patients (18%)
Lung squamous cell carcinoma
LUSC
27 patients (15%)
combined cohort
PanCan
665 patients (14%)
Glioblastoma multiforme
GBM
32 patients (10%)
Lung adenocarcinoma
LUAD
18 patients (4%)
PIK3CA is significantly mutated in
Esophageal adenocarcinoma
ESO
5 patients (3%)
PIK3CA is near significance in
Melanoma
MEL
5 patients (4%)
Kidney clear cell
KIRC
12 patients (2%)
Prostate
PRAD
3 patients (2%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PIK3CA