FAM123B Back

family with sequence similarity 123B

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NCBI Description of FAM123B

The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS).

Community Annotation of FAM123B Add / Edit FAM123B: Annotations

No community annotations yet for FAM123B.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


FAM123B is highly significantly mutated in
FAM123B is significantly mutated in
FAM123B is near significance in
26 patients (11%)
Esophageal adenocarcinoma
1 patient (0%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for FAM123B