v-raf murine sarcoma viral oncogene homolog B1

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NCBI Description of BRAF

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.

Community Annotation of BRAF Add / Edit BRAF: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


BRAF is highly significantly mutated in
75 patients (63%)
22 patients (9%)
Lung adenocarcinoma
27 patients (6%)
Multiple myeloma
13 patients (6%)
combined cohort
175 patients (3%)
BRAF is significantly mutated in
Diffuse large B-cell lymphoma
3 patients (5%)
Glioblastoma multiforme
6 patients (2%)
BRAF is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for BRAF