TBL1XR1 Back

transducin (beta)-like 1 X-linked receptor 1

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NCBI Description of TBL1XR1

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Community Annotation of TBL1XR1 Add / Edit TBL1XR1: Annotations

No community annotations yet for TBL1XR1.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TBL1XR1 is highly significantly mutated in
TBL1XR1 is significantly mutated in
13 patients (5%)
combined cohort
57 patients (1%)
10 patients (1%)
TBL1XR1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TBL1XR1