spen homolog, transcriptional regulator (Drosophila)

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NCBI Description of SPEN

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.

Community Annotation of SPEN Add / Edit SPEN: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SPEN is highly significantly mutated in
18 patients (2%)
SPEN is significantly mutated in
SPEN is near significance in
combined cohort
151 patients (3%)
Chronic lymphocytic leukemia
4 patients (2%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SPEN