RUNX1 Back

runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)

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NCBI Description of RUNX1

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Community Annotation of RUNX1 Add / Edit RUNX1: Annotations

No community annotations yet for RUNX1.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RUNX1 is highly significantly mutated in
Acute myeloid leukemia
17 patients (8%)
25 patients (2%)
combined cohort
70 patients (1%)
RUNX1 is significantly mutated in
RUNX1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RUNX1