NCOR1 Back

nuclear receptor co-repressor 1

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NCBI Description of NCOR1

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.

Community Annotation of NCOR1 Add / Edit NCOR1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NCOR1 is highly significantly mutated in
34 patients (3%)
NCOR1 is significantly mutated in
NCOR1 is near significance in
6 patients (5%)
Head and neck
14 patients (3%)
combined cohort
122 patients (2%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NCOR1