MYB Back

v-myb myeloblastosis viral oncogene homolog (avian)

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NCBI Description of MYB

This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.

Community Annotation of MYB Add / Edit MYB: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MYB is highly significantly mutated in
MYB is significantly mutated in
11 patients (1%)
MYB is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MYB