MLL3 Back

myeloid/lymphoid or mixed-lineage leukemia 3

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NCBI Description of MLL3

This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation.

Community Annotation of MLL3 Add / Edit MLL3: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MLL3 is highly significantly mutated in
59 patients (6%)
combined cohort
294 patients (6%)
MLL3 is significantly mutated in
MLL3 is near significance in
24 patients (24%)
Lung adenocarcinoma
60 patients (14%)
Head and neck
26 patients (6%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MLL3