MAP3K1 Back

mitogen-activated protein kinase kinase kinase 1

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NCBI Description of MAP3K1

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MAP3K1 is highly significantly mutated in
Breast
BRCA
59 patients (6%)
combined cohort
PanCan
118 patients (2%)
MAP3K1 is significantly mutated in
Glioblastoma multiforme
GBM
6 patients (2%)
MAP3K1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MAP3K1