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GATA binding protein 3

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NCBI Description of GATA3

This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GATA3 is highly significantly mutated in
84 patients (9%)
combined cohort
119 patients (2%)
GATA3 is significantly mutated in
GATA3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GATA3