CUL4B Back

cullin 4B

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NCBI Description of CUL4B

This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CUL4B Add / Edit CUL4B: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CUL4B is highly significantly mutated in
CUL4B is significantly mutated in
7 patients (0%)
CUL4B is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CUL4B