CCCTC-binding factor (zinc finger protein)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CTCF

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CTCF Add / Edit CTCF: Annotations

No community annotations yet for CTCF.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CTCF is highly significantly mutated in
46 patients (18%)
20 patients (2%)
combined cohort
99 patients (2%)
CTCF is significantly mutated in
Head and neck
12 patients (3%)
CTCF is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CTCF