XPO1 Back

exportin 1 (CRM1 homolog, yeast)

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NCBI Description of XPO1
The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.

Community Annotation of XPO1 Add / Edit XPO1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

XPO1 is highly significantly mutated in
Chronic lymphocytic leukemia
CLL
4 patients (2%)
XPO1 is significantly mutated in
XPO1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for XPO1