U2AF1 Back

U2 small nuclear RNA auxiliary factor 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of U2AF1

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.

Community Annotation of U2AF1 Add / Edit U2AF1: Annotations

No community annotations yet for U2AF1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


U2AF1 is highly significantly mutated in
Acute myeloid leukemia
8 patients (4%)
Lung adenocarcinoma
12 patients (2%)
combined cohort
34 patients (0%)
U2AF1 is significantly mutated in
U2AF1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for U2AF1