TNFRSF14 Back

tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

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NCBI Description of TNFRSF14
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.

Community Annotation of TNFRSF14 Add / Edit TNFRSF14: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNFRSF14 is highly significantly mutated in
Diffuse large B-cell lymphoma
DLBCL
8 patients (13%)
TNFRSF14 is significantly mutated in
TNFRSF14 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TNFRSF14