STK19 Back

serine/threonine kinase 19

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NCBI Description of STK19
This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants.

Community Annotation of STK19 Add / Edit STK19: Annotations

Please see Rodriguez-Martinez M, et al. 2020, Cell 181, 1395–1405, for the corrected annotation: https://www.cell.com/action/showPdf?pii=S0092-8674%2820%2930476-1

In the corrected annotation the protein starts at amino acid 111 of the old annotation. Any mutations corresponding to DNA before amino acid 111 are thus in the regulatory region. The recurrent C>T mutation (‘D89N’) does not affect expression of the gene.

Added by Marta Rodriguez Martinez

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

STK19 is highly significantly mutated in
STK19 is significantly mutated in
Melanoma
MEL
4 patients (3%)
STK19 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for STK19