STK11 Back

serine/threonine kinase 11

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NCBI Description of STK11

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Community Annotation of STK11 Add / Edit STK11: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


STK11 is highly significantly mutated in
Lung adenocarcinoma
42 patients (10%)
combined cohort
52 patients (1%)
STK11 is significantly mutated in
STK11 is near significance in
Lung squamous cell carcinoma
3 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for STK11