SOX6 Back

SRY (sex determining region Y)-box 6

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SOX6

This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.

Community Annotation of SOX6 Add / Edit SOX6: Annotations

No community annotations yet for SOX6.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SOX6 is highly significantly mutated in
SOX6 is significantly mutated in
SOX6 is near significance in
combined cohort
50 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SOX6