SOS1 Back

son of sevenless homolog 1 (Drosophila)

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NCBI Description of SOS1
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4.

Community Annotation of SOS1 Add / Edit SOS1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SOS1 is highly significantly mutated in
SOS1 is significantly mutated in
Endometrial
UCEC
15 patients (6%)
SOS1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SOS1