SLC26A3 Back

solute carrier family 26, member 3

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NCBI Description of SLC26A3
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea.

Community Annotation of SLC26A3 Add / Edit SLC26A3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC26A3 is highly significantly mutated in
Glioblastoma multiforme
GBM
7 patients (2%)
SLC26A3 is significantly mutated in
SLC26A3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC26A3