SGK1 Back

serum/glucocorticoid regulated kinase 1

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NCBI Description of SGK1
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Community Annotation of SGK1 Add / Edit SGK1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SGK1 is highly significantly mutated in
SGK1 is significantly mutated in
Endometrial
UCEC
16 patients (6%)
SGK1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SGK1