SELP Back

selectin P (granule membrane protein 140kDa, antigen CD62)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SELP
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.

Community Annotation of SELP Add / Edit SELP: Annotations

No community annotations yet for SELP.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SELP is highly significantly mutated in
SELP is significantly mutated in
Endometrial
UCEC
11 patients (4%)
SELP is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SELP