RXRA Back

retinoid X receptor, alpha

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NCBI Description of RXRA
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RXRA is highly significantly mutated in
Bladder
BLCA
9 patients (9%)
RXRA is significantly mutated in
RXRA is near significance in
Melanoma
MEL
6 patients (5%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RXRA