RIT1 Back

Ras-like without CAAX 1

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NCBI Description of RIT1

Community Annotation of RIT1 Add / Edit RIT1: Annotations

RIT1 is a RAS-subfamily small GTPase that is expressed in most tissues. RIT1 mutations have been identified in somatic cancers as well as the germline "RAS-opathy", Noonan syndrome. Molecular studies indicate that RIT1 can activate MEK and p38 signaling and can transform rodent and human cells via activation of MEK and PI3K signaling.

RIT1 mutations are mutually exclusive with other RAS-pathway mutations in all diseases studied thus far (myeloid leukemias, lung adenocarcinoma, and Noonan syndrome).


Added by Alice Berger


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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RIT1 is highly significantly mutated in
Lung adenocarcinoma
14 patients (3%)
RIT1 is significantly mutated in
RIT1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RIT1