NCBI Description of RIT1
Community Annotation of RIT1 Add / Edit RIT1: Annotations
RIT1 is a RAS-subfamily small GTPase that is expressed in most tissues. RIT1 mutations have been identified in somatic cancers as well as the germline "RAS-opathy", Noonan syndrome. Molecular studies indicate that RIT1 can activate MEK and p38 signaling and can transform rodent and human cells via activation of MEK and PI3K signaling.
RIT1 mutations are mutually exclusive with other RAS-pathway mutations in all diseases studied thus far (myeloid leukemias, lung adenocarcinoma, and Noonan syndrome).
Added by Alice Berger
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