RBM5 Back

RNA binding motif protein 5

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NCBI Description of RBM5
This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer.

Community Annotation of RBM5 Add / Edit RBM5: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RBM5 is highly significantly mutated in
RBM5 is significantly mutated in
RBM5 is near significance in
Head and neck
HNSC
6 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RBM5