RBBP4 Back

retinoblastoma binding protein 4

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NCBI Description of RBBP4
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.

Community Annotation of RBBP4 Add / Edit RBBP4: Annotations

No community annotations yet for RBBP4.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RBBP4 is highly significantly mutated in
RBBP4 is significantly mutated in
RBBP4 is near significance in
Acute myeloid leukemia
AML
2 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RBBP4