RAD21 Back

RAD21 homolog (S. pombe)

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NCBI Description of RAD21
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RAD21 is highly significantly mutated in
RAD21 is significantly mutated in
Acute myeloid leukemia
AML
6 patients (3%)
RAD21 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RAD21