PTPN11 Back

protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)

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NCBI Description of PTPN11

Community Annotation of PTPN11 Add / Edit PTPN11: Annotations

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Sort mutations by: Tumor type  Mutation type  Position  
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PTPN11 is highly significantly mutated in
Acute myeloid leukemia
10 patients (5%)
PTPN11 is significantly mutated in
PTPN11 is near significance in
3 patients (3%)
Glioblastoma multiforme
5 patients (1%)
Multiple myeloma
3 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PTPN11