PRDM1 Back

PR domain containing 1, with ZNF domain

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NCBI Description of PRDM1

This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.

Community Annotation of PRDM1 Add / Edit PRDM1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PRDM1 is highly significantly mutated in
PRDM1 is significantly mutated in
Multiple myeloma
6 patients (2%)
PRDM1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PRDM1