PPP2R1A Back

protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform

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NCBI Description of PPP2R1A
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.

Community Annotation of PPP2R1A Add / Edit PPP2R1A: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPP2R1A is highly significantly mutated in
Endometrial
UCEC
30 patients (12%)
PPP2R1A is significantly mutated in
PPP2R1A is near significance in
combined cohort
PanCan
67 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPP2R1A