polymerase (RNA) II (DNA directed) polypeptide B, 140kDa

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NCBI Description of POLR2B

This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


POLR2B is highly significantly mutated in
POLR2B is significantly mutated in
POLR2B is near significance in
combined cohort
62 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for POLR2B