PLCG2 Back

phospholipase C, gamma 2 (phosphatidylinositol-specific)

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NCBI Description of PLCG2

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PLCG2 is highly significantly mutated in
PLCG2 is significantly mutated in
combined cohort
73 patients (1%)
PLCG2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PLCG2