PDSS2 Back

prenyl (decaprenyl) diphosphate synthase, subunit 2

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NCBI Description of PDSS2
The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PDSS2 is highly significantly mutated in
PDSS2 is significantly mutated in
Acute myeloid leukemia
AML
2 patients (1%)
PDSS2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PDSS2