PBRM1 Back

polybromo 1

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NCBI Description of PBRM1

This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.

Community Annotation of PBRM1 Add / Edit PBRM1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PBRM1 is highly significantly mutated in
Kidney clear cell
146 patients (35%)
combined cohort
210 patients (4%)
PBRM1 is significantly mutated in
PBRM1 is near significance in
12 patients (4%)
Head and neck
9 patients (2%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PBRM1