NT5E Back

5'-nucleotidase, ecto (CD73)

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NCBI Description of NT5E
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of NT5E Add / Edit NT5E: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NT5E is highly significantly mutated in
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NT5E is significantly mutated in
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NT5E is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NT5E