NPM1 Back

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

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NCBI Description of NPM1

This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

Community Annotation of NPM1 Add / Edit NPM1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NPM1 is highly significantly mutated in
Acute myeloid leukemia
34 patients (17%)
combined cohort
43 patients (0%)
NPM1 is significantly mutated in
NPM1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NPM1