NFE2L2 Back

nuclear factor (erythroid-derived 2)-like 2

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NCBI Description of NFE2L2

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NFE2L2 is highly significantly mutated in
Lung squamous cell carcinoma
27 patients (15%)
9 patients (9%)
Head and neck
21 patients (5%)
combined cohort
95 patients (2%)
NFE2L2 is significantly mutated in
NFE2L2 is near significance in
16 patients (6%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NFE2L2