NEO1 Back

neogenin homolog 1 (chicken)

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NCBI Description of NEO1
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants.

Community Annotation of NEO1 Add / Edit NEO1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NEO1 is highly significantly mutated in
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NEO1 is significantly mutated in
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NEO1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NEO1