MYD88 Back

myeloid differentiation primary response gene (88)

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NCBI Description of MYD88

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.

Community Annotation of MYD88 Add / Edit MYD88: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MYD88 is highly significantly mutated in
Diffuse large B-cell lymphoma
7 patients (12%)
Chronic lymphocytic leukemia
12 patients (7%)
combined cohort
31 patients (0%)
MYD88 is significantly mutated in
MYD88 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MYD88