KIT Back

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

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NCBI Description of KIT
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KIT is highly significantly mutated in
Acute myeloid leukemia
AML
8 patients (4%)
KIT is significantly mutated in
KIT is near significance in
Melanoma
MEL
4 patients (3%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KIT