KDM6A Back

lysine (K)-specific demethylase 6A

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NCBI Description of KDM6A

This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


KDM6A is highly significantly mutated in
27 patients (27%)
combined cohort
91 patients (1%)
KDM6A is significantly mutated in
KDM6A is near significance in
Head and neck
8 patients (2%)
Acute myeloid leukemia
3 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for KDM6A