ITPKB Back

inositol 1,4,5-trisphosphate 3-kinase B

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ITPKB
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

Community Annotation of ITPKB Add / Edit ITPKB: Annotations

No community annotations yet for ITPKB.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ITPKB is highly significantly mutated in
ITPKB is significantly mutated in
Diffuse large B-cell lymphoma
DLBCL
6 patients (10%)
ITPKB is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ITPKB