IRF4 Back

interferon regulatory factor 4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of IRF4
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.

Community Annotation of IRF4 Add / Edit IRF4: Annotations

No community annotations yet for IRF4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IRF4 is highly significantly mutated in
IRF4 is significantly mutated in
Multiple myeloma
MM
4 patients (1%)
IRF4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IRF4